CSF1R T567M mutation induces microglial dysfunction and synaptic impairment in patient iPSC-derived cerebral organoids of CSF1R-related disorder

📢 Publication alert 📢

Excited to share this new paper published in Cell Death Discovery:
“CSF1R T567M mutation induces microglial dysfunction and synaptic impairment in patient iPSC-derived cerebral organoids of CSF1R-related disorder.”

This study uses patient iPSC-derived microglia and cerebral organoids to model CSF1R-related disorder, showing that the T567M mutation leads to neuroinflammation in mutated CSF1R iPSC-derived microglia. Furthermore, pathogenesis driven by CSF1R-T567M mutation was exclusively studied, highlighting the critical role of CSF1R signaling in neural homeostasis.

Big congratulations to Li Chi, Li Zeng teams and many more for the hard work and dedication behind this study 👏

👉 https://lnkd.in/gZeb35Vw