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Cell Fate Engineering & Therapeutics Lab - Cell Fate Engineering Lab Cell Fate Engineering & Therapeutics Lab - Cell Fate Engineering Lab
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Publication - Cell Fate Engineering Lab
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Publication

  • Correia C, Ung CY, Zhang Z, Blissenbach E, Zhu S, Billadeau DD, Loh YH, Li H

    Mini-Galaxy: Rethinking Complex Human Diseases Through the Lens of Systems Biology and Multilayered AI Network Perspectives. Int J Mol Sci.

    2026 Mar 31;27(7):3161. doi:10.3390/ijms27073161

  • Chi, L., Tu, H., Li, Z., Qiu, L., Zhang, Z.-W., Chia, S.-Y., Tan, J. Y., Ho, I. A. W., Loh, Y.-H., Tan, E.-K., Teng, W., Pei, Z., Wszolek, Z. K., Ng, A. S. L., & Zeng, L.

    CSF1R T567M mutation induces microglial dysfunction and synaptic impairment in patient iPSC-derived cerebral organoids of CSF1R-related disorder. Cell Death Discovery

    2026 Mar 12; ahead of print. doi: 10.1038/s41420-026-02995-2.

  • Kamaraj US, Chen Y, Lei J, Gautam P, Horcharoensuk P, Clemente CKM, Weinacht KG, Gascoigne NRJ, Chen J, Chen CK, Chen Q, Li QJ, Ng LG, Loh YH

    Spatial cartography of human thymus enables the geopositioning of lineage transcription factors in rare mimetic thymic epithelial cells. Nat Commun.

    2026 Mar 10. doi:10.1038/s41467-026-68596-w.

  • De Los Angeles A, Bayne T, Benvenisty N, Deng H, Fujita M, Ji W, Latham S, Li T, Liu P, Loh YH, Lunshof J, Pei D, Pho N, Silva JCR, Ka Ki Tam TT, Tao T, Trounson A, Xu S, Yu L, Koplin J, Regenberg A, Sugaya K, Savulescu J, Zernicka-Goetz M, Lovell-Badge R

    A two-tier framework for responsible research on human embryo models. Cell.

    2026 Jan 22;189(2):348-355. doi: 10.1016/j.cell.2025.12.006. PMID: 41576917.

  • Liang Y, Grinchuk OV, Cipta NO, Zeng Y, Chuah YH, Yoon J, Khong ZJ, Chow HY, Ng W, Ong CT, Ling SC, Ng SY, Loh YH, Ong DST

    DMTF1 up-regulation rescues proliferation defect of telomere dysfunctional neural stem cells via the SWI/SNF-E2F axis. Sci Adv.

    2026 Jan 2;12(1):eady5905. doi: 10.1126/sciadv.ady5905. Epub 2026 Jan 2. PMID: 41481722; PMCID: PMC12758551.

  • Liu TM, Tew W, Yang Z, Lim B, Hui JHP, Lee EH, Loh YH, Cool S

    Understanding the molecular basis of mesenchymal stem cell stemness: implications for clinical applications. Cell Death Dis.

    2025 Nov 3;16(1):778. doi: 10.1038/s41419-025-08094-x. PMID: 41184233; PMCID: PMC12583528.

  • Xiaotong Yu, Yanan Hu, Hwee Ying Lim, Ziyi Li, Diego Adhemar Jaitin, Katharine Yang, Wan Ting Kong, Jiaqian Xu, David Alejandro Bejarano, Mathilde Bied, Lucie Orliaguet, Gowshika Rengasamy, Zachary Chow, Christopher Zhe Wei Lee, Josephine Lum, Jing Tian, Xiao-Meng Zhang, Honghao Liu, Shu Wen Tan, Jinmiao Chen, Peter See, Yuin-Han Loh, Benoit Malleret, Sonia Baig, M Shabeer M Yassin, Sue-Anne Ee Shiow Toh, Bernard Malissen, Xiujun Fu, Kenji Kabashima, Lai Guan Ng, Camille Blériot, Zhaoyuan Liu, Lingling Sheng, Dan-Ning Zheng, Junwen Qu, Nicolas Venteclef, Bing Su, Ido Amit, Andreas Schlitzer, Veronique Angeli, Florent Ginhoux, Svetoslav Chakarov

    Septal LYVE1+ macrophages control adipocyte stem cell adipogenic potential Science

    2025 Aug 28;389(6763). doi: 10.1126/science.adg1128

  • Brenda Wan Shing Lam, Melissa Tan, Chang Gao, Thach Tuan Pham, Lan Thi Ngoc Tran, Lan Ngoc Nguyen, Harwin Sidik, Matthias BH Lim, Anh Hong Le, Tram TT Nguyen, Nicole Lim, Lap Nguyen, Thuy Huong Nguyen, Yuin‐Han Loh, Muhammad Waqas Usman, Minh TN Le

    Extracellular Vesicles Administered via Intrathecal Injection Mediate Safe Delivery of Nucleic Acids to the Central Nervous System for Gene Therapy Journal of Extracellular Vesicles

    2025 Jul 7;14(7). doi: 10.1002/jev2.70116

  • Cao Dai Phung, Trinh TT Tran, Brendon Zhi Jie Yeo, Rebecca Carissa Prajogo, Evelyn Saudjana, Eric Yew Meng Yeo, Chang Gao, Phuong HD Nguyen, Migara Kavishka Jayasinghe, Xuan TT Dang, Celest Phang Lixuan, Trinh Mai Nguyen, Boya Peng, Anh Hong Le, Tram TT Nguyen, Gloria Mei En Chan, Yuin-Han Loh, Boon Cher Goh, Wai Leong Tam, Glenn Kunnath Bonney, Dahai Luo, Minh TN Le

    Combination of KRAS ASO and RIG-I agonist in extracellular vesicles transforms the tumor microenvironment towards effective treatment of KRAS-dependent cancers Theranostics

    2025 Jun 9;15(14):6818–38. doi: 10.7150/thno.105519

  • Samiyah Shafiq, Kiyofumi Hamashima, Laura A Guest, Ali H Al-Anbaki, Fabio MR Amaral, Daniel H Wiseman, Valerie Kouskoff, Georges Lacaud, Yuin-Han Loh, Kiran Batta

    Competing dynamic gene regulatory networks involved in fibroblast reprogramming to hematopoietic progenitor cells Stem Cell Reports

    2025 May;20(5):102473. doI: 10.1016/j.stemcr.2025.102473

  • Cipta NO, Zeng Y, Wong KW, Zheng ZH, Yi Y, Warrier T, Teo JZ, Teo JHJ, Kok YJ, Bi X, Taneja R, Ong DST, Xu J, Ginhoux F, Li H, Liou YC, Loh YH

    Rewiring of SINE-MIR enhancer topology and Esrrb modulation in expanded and naive pluripotency. Genome Biol.

    2025 Apr 28;26(1):107. doi: 10.1186/s13059-025-03577-8. PMID: 40296153; PMCID: PMC12036290.

  • Grapin-Botton A, Loh JY.

    Editorial overview: Regaining architecture and cell cross-talk upon regeneration. Curr Opin Genet Dev.

    2025 Apr;91:102302. doi: 10.1016/j.gde.2024.102302. Epub 2024 Dec 28. PMID: 39733467.

  • Diyuan Qin, Yanna Lei, Pei Shu, Yugu Zhang, Yuin-Han Loh, Yongsheng Wang, Qijing Li

    Supercharging CAR-T cells through transcriptional and epigenetic armoring Theranostics

    2025 Feb 18;15(8):3345–67. doI: 10.7150/thno.107908

  • Hai-Jun Liu, Serena Jocelyn Wai Yin Oh, Nicole Liling Tay, Christina Yingyan Lim, Chia-Da Hsu, Delia Hwee Hoon Chua, Winnie Koon Lay Teo, Yuin-Han Loh, Soon Chye Ng

    Morphokinetic Analyses of Fishing Cat–Domestic Cat Interspecies Somatic Cell Nuclear Transfer Embryos Through A Time-Lapse System Animals

    2025 Jan 9;15(2):148. doI: 10.3390/ani15020148

  • Chooi WH, Winanto, Zeng Y, Lee CY, Lim ZQ, Gautam P, Chu JJH, Loh YH, Alonso S, Ng SY

    Enterovirus-A71 preferentially infects and replicates in human motor neurons, inducing neurodegeneration by ferroptosis. Emerg Microbes Infect.

    2024 Dec;13(1):2382235. doi: 10.1080/22221751.2024.2382235. Epub 2024 Jul 25. PMID: 39017655; PMCID: PMC11285248.

  • Wong KW, Zeng Y, Tay E, Teo JHJ, Cipta NO, Hamashima K, Yi Y, Liu H, Warrier T, Le MTN, Ng SC, Li QJ, Li H, Loh YH

    Nuclear receptor-SINE B1 network modulates expanded pluripotency in blastoids and blastocysts. Nat Commun.

    2024 Nov 19;15(1):10011. doi: 10.1038/s41467-024-54381-0. PMID: 39562549; PMCID: PMC11577042.

  • Kamaraj US, Gautam P, Cheng T, Chin TS, Tay SK, Ho TH, Nadarajah R, Goh RCH, Wong SL, Mantoo S, Busmanis I, Li H, Le MT, Li QJ, Lim EH, Loh YH

    Deciphering tumour microenvironment and elucidating the origin of cancer cells in ovarian clear cell carcinoma. bioRxiv [Preprint].

    2024 Aug 8:2024.08.06.606821. doi: 10.1101/2024.08.06.606821. PMID: 39149248; PMCID: PMC11326226.

  • Feng J, Chuah YH, Liang Y, Cipta NO, Zeng Y, Warrier T, Elfar GARE, Yoon J, Grinchuk OV, Tay EXY, Lok KZ, Zheng ZQ, Khong ZJ, Chong ZS, Teo J, Sanford EM, Neo CJY, Chiu HY, Leung JY, Wang LC, Lim YT, Zhao T, Sobota RM, Crasta KC, Tergaonkar V, Taneja R, Ng SY, Cheok CF, Ling SC, Loh YH, Ong DST

    PHF2 regulates genome topology and DNA replication in neural stem cells via cohesin. Nucleic Acids Res.

    2024 Jul 8;52(12):7063-7080. doi: 10.1093/nar/gkae457. PMID: 38808662; PMCID: PMC11229317.

  • Yin T, Wang G, Wang L, Mudgal P, Wang E, Pan CC, Alexander PB, Wu H, Cao C, Liang Y, Tan L, Huang D, Chong M, Chen R, Lim BJW, Xiang K, Xue W, Wan L, Hu H, Loh YH, Wang XF, Li QJ

    Breaking NGF-TrkA immunosuppression in melanoma sensitizes immunotherapy for durable memory T cell protection. Nat Immunol.

    2024 Feb;25(2):268-281. doi: 10.1038/s41590-023-01723-7. Epub 2024 Jan 9. PMID: 38195702; PMCID: PMC11377935.

  • Bao Q, Tay NL, Lim CY, Chua DHH, Kee SK, Choolani M, Loh YH, Ng SC, Chai C

    Integration-free induced pluripotent stem cells from three endangered Southeast Asian non-human primate species. Sci Rep.

    2024 Jan 29;14(1):2391. doi: 10.1038/s41598-023-50510-9. PMID: 38287040; PMCID: PMC10825216.

  • Ng MSF, Kwok I, Tan L, Shi C, Cerezo-Wallis D, Tan Y, Leong K, Calvo GF, Yang K, Zhang Y, Jin J, Liong KH, Wu D, He R, Liu D, Teh YC, Bleriot C, Caronni N, Liu Z, Duan K, Narang V, Ballesteros I, Moalli F, Li M, Chen J, Liu Y, Liu L, Qi J, Liu Y, Jiang L, Shen B, Cheng H, Cheng T, Angeli V, Sharma A, Loh YH, Tey HL, Chong SZ, Iannacone M, Ostuni R, Hidalgo A, Ginhoux F, Ng LG

    Deterministic reprogramming of neutrophils within tumors. Science.

    2024 Jan 12;383(6679):eadf6493. doi: 10.1126/science.adf6493. Epub 2024 Jan 12. PMID: 38207030; PMCID: PMC11087151.

  • Viswanathan R, Cheruba E, Wong PM, Yi Y, Ngang S, Chong DQ, Loh YH, Tan IB, Cheow LF

    DARESOME enables concurrent profiling of multiple DNA modifications with restriction enzymes in single cells and cell-free DNA. Sci Adv.

    2023 Sep 15;9(37):eadi0197. doi: 10.1126/sciadv.adi0197. Epub 2023 Sep 15. PMID: 37713482; PMCID: PMC10881072.

  • Hamashima K, Wong KW, Sam TW, Teo JHJ, Taneja R, Le MTN, Li QJ, Hanna JH, Li H, Loh YH

    Single-nucleus multiomic mapping of m6A methylomes and transcriptomes in native populations of cells with sn-m6A-CT. Mol Cell.

    2023 Aug 25:S1097-2765(23)00649-4. doi: 10.1016/j.molcel.2023.08.010. Epub ahead of print. PMID: 37657444; PMCID: PMC10895704.

  • Pham TT, Le AH, Dang CP, Chong SY, Do DV, Peng B, Jayasinghe MK, Ong HB, Hoang DV, Louise RA, Loh YH, Hou HW, Wang JW, Le MT

    Endocytosis of red blood cell extracellular vesicles by macrophages leads to cytoplasmic heme release and prevents foam cell formation in atherosclerosis. J Extracell Vesicles.

    2023 Aug;12(8):e12354. doi: 10.1002/jev2.12354. PMID: 37553837; PMCID: PMC10410060.

  • Murray A, Gough G, Cindri? A, Vu?kovi? F, Koschut D, Borelli V, Petrovi? DJ, Bekavac A, Ple?aö A, Hribljan V, Brunmeir R, Juri? J, Pu?i?-Bakovi? M, Slana A, Deriö H, Frkatovi? A, Groet J, O'Brien NL, Chen HY, Yeap YJ, Delom F, Havlicek S, Gammon L, Hamburg S, Startin C, D'Souza H, Mitre?i? D, Kero M, Odak L, Kruölin B, Krsnik é, Kostovi? I, Foo JN, Loh YH, Dunn NR, de la Luna S, Spector T, Bariöi? I, Thomas MSC, Strydom A, Franceschi C, Lauc G, Kriöti? J, Ali? I, Niûeti?

    Dose imbalance of DYRK1A kinase causes systemic progeroid status in Down syndrome by increasing the un-repaired DNA damage and reducing LaminB1 levels. EBioMedicine.

    2023 Aug;94:104692. doi: 10.1016/j.ebiom.2023.104692. Epub 2023 Jul 12. PMID: 37451904; PMCID: PMC10435767.

  • Li H, Zhang J, Loh YH, Billadeau DD

    Editorial: Decoding immunologic complex systems in cancer: the cutting-edge technologies revolutionizing cancer immunology and immunotherapy. Front Immunol.

    2023 May 4;14:1208589. doi: 10.3389/fimmu.2023.1208589. PMID: 37215101; PMCID: PMC10196616.

  • Yi Y, Zeng Y, Sam TW, Hamashima K, Tan RJR, Warrier T, Phua JX, Taneja R, Liou YC, Li H, Xu J, Loh YH

    Ribosomal proteins regulate 2-cell-stage transcriptome in mouse embryonic stem cells. Stem Cell Reports.

    2023 Feb 14;18(2):463-474. doi: 10.1016/j.stemcr.2022.12.007. Epub 2023 Jan 12. PMID: 36638791; PMCID: PMC9968990.

  • Perlin JR, Anderson WJ, Bartfeld S, Couturier A, de Soysa Y, Hawley RS, Hu P, Loh YH, Mandal L, Master Z, Muotri AR, Piddini E, Polo JM, Mazzoni EO

    ISSCR Education Committee syllabus and learning guide for enhancing stem cell literacy. Stem Cell Reports.

    2023 Feb 14;18(2):417-419. doi: 10.1016/j.stemcr.2022.12.004. Epub 2023 Jan 12. PMID: 36638789; PMCID: PMC9968981.

  • Ho BX, Pang JKS, Chen Y, Loh YH, An O, Yang HH, Seshachalam VP, Koh JLY, Chan WK, Ng SY, Soh BS

    Robust generation of human-chambered cardiac organoids from pluripotent stem cells for improved modelling of cardiovascular diseases. Stem Cell Res Ther.

    2022 Dec 21;13(1):529. doi: 10.1186/s13287-022-03215-1. PMID: 36544188; PMCID: PMC9773542.

  • De Los Angeles A, Regenberg A, Mascetti V, Benvenisty N, Church G, Deng H, Izpisua Belmonte JC, Ji W, Koplin J, Loh YH, Niu Y, Pei D, Pera M, Pho N, Pinzon-Arteaga C, Saitou M, Silva JCR, Tao T, Trounson A, Warrier T, Zambidis ET

    Why it is important to study human-monkey embryonic chimeras in a dish. Nat Methods.

    2022 Aug;19(8):914-919. doi: 10.1038/s41592-022-01571-7. PMID: 35879609; PMCID: PMC9780756.

  • Warrier T, El Farran C, Zeng Y, Ho BSQ, Bao Q, Zheng ZH, Bi X, Ng HH, Ong DST, Chu JJH, Sanyal A, Fullwood MJ, Collins JJ, Li H, Xu J, Loh YH

    SETDB1 acts as a topological accessory to Cohesin via an H3K9me3-independent, genomic shunt for regulating cell fates. Nucleic Acids Res.

    2022 Jul 22;50(13):7326-7349. doi: 10.1093/nar/gkac531. PMID: 35776115; PMCID: PMC9303280.

  • Goh CJH, Wong JH, El Farran C, Tan BX, Coffill CR, Loh YH, Lane D, Arumugam P

    Correction to: Identification of pathways modulating vemurafenib resistance in melanoma cells via a genome-wide CRISPR/Cas9 screen. G3 (Bethesda).

    2022 Mar 4;12(3):jkac024. doi: 10.1093/g3journal/jkac024. Erratum for: G3 (Bethesda). 2021 Feb 9;11(2):jkaa069. doi: 10.1093/g3journal/jkaa069. PMID: 35169844; PMCID: PMC8895985.

  • Yu S, Li J, Ji G, Ng ZL, Siew J, Lo WN, Ye Y, Chew YY, Long YC, Zhang W, Guccione E, Loh YH, Jiang ZH, Yang H, Wu Q

    Npac Is A Co-factor of Histone H3K36me3 and Regulates Transcriptional Elongation in Mouse Embryonic Stem Cells. Genomics Proteomics Bioinformatics.

    2022 Feb;20(1):110-128. doi: 10.1016/j.gpb.2020.08.004. Epub 2021 Mar 4. PMID: 33676077; PMCID: PMC9510873.

  • Cipta NO, Chen Y, Loh YH

    H3.3 safeguards haematopoietic ERV-quilibrium. Nat Cell Biol.

    2022 Jan;24(1):7-9. doi: 10.1038/s41556-021-00758-y. PMID: 34961795.

  • Gautam P, Hamashima K, Chen Y, Zeng Y, Makovoz B, Parikh BH, Lee HY, Lau KA, Su X, Wong RCB, Chan WK, Li H, Blenkinsop TA, Loh YH

    Multi-species single-cell transcriptomic analysis of ocular compartment regulons. Nat Commun.

    2021 Sep 28;12(1):5675. doi: 10.1038/s41467-021-25968-8. PMID: 34584087; PMCID: PMC8478974.

  • Sriram S, Kang NY, Subramanian S, Nandi T, Sudhagar S, Xing Q, Tong GJ, Chen AK, Srijaya TC, Tan P, Loh YH, Chang YT, Sugii S

    Novel live cell fluorescent probe for human-induced pluripotent stem cells highlights early reprogramming population. Stem Cell Res Ther.

    2021 Feb 5;12(1):113. doi: 10.1186/s13287-021-02171-6. PMID: 33546754; PMCID: PMC7866770.

  • Zheng ZH, Sam TW, Zeng Y, Chu JJH, Loh YH

    Chromatin Regulation in Development: Current Understanding and Approaches. Stem Cells Int.

    2021 Feb 2;2021:8817581. doi: 10.1155/2021/8817581. PMID: 33603792; PMCID: PMC7872760.

  • Sivalingam J, SuE Y, Lim ZR, Lam ATL, Lee AP, Lim HL, Chen HY, Tan HK, Warrier T, Hang JW, Nazir NB, Tan AHM, Renia L, Loh YH, Reuveny S, Malleret B, Oh SKW

    A Scalable Suspension Platform for Generating High-Density Cultures of Universal Red Blood Cells from Human Induced Pluripotent Stem Cells. Stem Cell Reports.

    2021 Jan 12;16(1):182-197. doi: 10.1016/j.stemcr.2020.11.008. Epub 2020 Dec 10. PMID: 33306988; PMCID: PMC7897557.

  • Wang HF, Warrier T, Farran CA, Zheng ZH, Xing QR, Fullwood MJ, Zhang LF, Li H, Xu J, Lim TM, Loh YH

    Defining Essential Enhancers for Pluripotent Stem Cells Using a Features-Oriented CRISPR-Cas9 Screen. Cell Rep.

    2020 Oct 27;33(4):108309. doi: 10.1016/j.celrep.2020.108309. PMID: 33113365.

  • Xing QR, El Farran CA, Gautam P, Chuah YS, Warrier T, Toh CD, Kang NY, Sugii S, Chang YT, Xu J, Collins JJ, Daley GQ, Li H, Zhang LF, Loh YH

    Diversification of reprogramming trajectories revealed by parallel single-cell transcriptome and chromatin accessibility sequencing. Sci Adv.

    2020 Sep 11;6(37):eaba1190. doi: 10.1126/sciadv.aba1190. PMID: 32917699; PMCID: PMC7486102

  • Xing QR, Cipta NO, Hamashima K, Liou YC, Koh CG, Loh YH

    Unraveling Heterogeneity in Transcriptome and Its Regulation Through Single-Cell Multi-Omics Technologies. Front Genet.

    2020 Jul 17;11:662. doi: 10.3389/fgene.2020.00662. PMID: 32765578; PMCID: PMC7380244.

  • Xing QR, Farran CAE, Zeng YY, Yi Y, Warrier T, Gautam P, Collins JJ, Xu J, DrAge P, Koh CG, Li H, Zhang LF, Loh YH

    Parallel bimodal single-cell sequencing of transcriptome and chromatin accessibility. Genome Res.

    2020 Jul;30(7):1027-1039. doi: 10.1101/gr.257840.119. Epub 2020 Jul 22. PMID: 32699019; PMCID: PMC7397874.

  • Liu TM, Yildirim ED, Li P, Fang HT, Denslin V, Kumar V, Loh YH, Lee EH, Cool SM, Teh BT, Hui JH, Lim B, Shyh-Chang N

    Ascorbate and Iron Are Required for the Specification and Long-Term Self-Renewal of Human Skeletal Mesenchymal Stromal Cells. Stem Cell Reports.

    2020 Feb 11;14(2):210-225. doi: 10.1016/j.stemcr.2020.01.002. Epub 2020 Jan 30. PMID: 32004493; PMCID: PMC7013236.

  • Chen Y, Yi Y, Xu J, Chan WK, Loh YH

    Re-entering the pluripotent state from blood lineage: promises and pitfalls of blood reprogramming. FEBS Lett.

    2019 Dec;593(23):3244-3252. doi: 10.1002/1873-3468.13659. Epub 2019 Nov 26. PMID: 31691960

  • He J, Fu X, Zhang M, He F, Li W, Abdul MM, Zhou J, Sun L, Chang C, Li Y, Liu H, Wu K, Babarinde IA, Zhuang Q, Loh YH, Chen J, Esteban MA, Hutchins AP

    Transposable elements are regulated by context-specific patterns of chromatin marks in mouse embryonic stem cells. Nat Commun.

    2019 Jan 3;10(1):34. doi: 10.1038/s41467-018-08006-y. PMID: 30604769; PMCID: PMC6318327.

  • Lee E, Sivalingam J, Lim ZR, Chia G, Shi LG, Roberts M, Loh YH, Reuveny S, Oh SK

    Review: In vitro generation of red blood cells for transfusion medicine: Progress, prospects and challenges. Biotechnol Adv.

    2018 Dec;36(8):2118-2128. doi: 10.1016/j.biotechadv.2018.09.006. Epub 2018 Sep 29. PMID: 30273713.

  • Sivalingam J, Chen HY, Yang BX, Lim ZR, Lam ATL, Woo TL, Chen AK, Reuveny S, Loh YH, Oh SK

    Improved erythroid differentiation of multiple human pluripotent stem cell lines in microcarrier culture by modulation of Wnt/I˝-Catenin signaling. Haematologica.

    2018 Jul;103(7):e279-e283. doi: 10.3324/haematol.2017.180919. Epub 2018 Mar 8. PMID: 29519863; PMCID: PMC6029542.

  • Fang HT, El Farran CA, Xing QR, Zhang LF, Li H, Lim B, Loh YH

    Global H3.3 dynamic deposition defines its bimodal role in cell fate transition. Nat Commun.

    2018 Apr 18;9(1):1537. doi: 10.1038/s41467-018-03904-7. PMID: 29670118; PMCID: PMC5906632.

  • Lee E, Lim ZR, Chen HY, Yang BX, Lam AT, Chen AK, Sivalingam J, Reuveny S, Loh YH, Oh SK

    Defined Serum-Free Medium for Bioreactor Culture of an Immortalized Human Erythroblast Cell Line. Biotechnol J.

    2018 Apr;13(4):e1700567. doi: 10.1002/biot.201700567. Epub 2018 Feb 6. PMID: 29330927.

  • Gautam P, Yu T, Loh YH

    Regulation of ERVs in pluripotent stem cells and reprogramming. Curr Opin Genet Dev.

    2017 Oct;46:194-201. doi: 10.1016/j.gde.2017.07.012. Epub 2017 Sep 1. PMID: 28866476.

  • Mzoughi S, Zhang J, Hequet D, Teo SX, Fang H, Xing QR, Bezzi M, Seah MKY, Ong SLM, Shin EM, Wollmann H, Wong ESM, Al-Haddawi M, Stewart CL, Tergaonkar V, Loh YH, Dunn NR, Messerschmidt DM, Guccione E

    PRDM15 safeguards naive pluripotency by transcriptionally regulating WNT and MAPK-ERK signaling. Nat Genet.

    2017 Sep;49(9):1354-1363. doi: 10.1038/ng.3922. Epub 2017 Jul 24. PMID: 28740264.

  • Cheng H, Ang HY, A El Farran C, Li P, Fang HT, Liu TM, Kong SL, Chin ML, Ling WY, Lim EK, Li H, Huber T, Loh KM, Loh YH, Lim B

    Reprogramming mouse fibroblasts into engraftable myeloerythroid and lymphoid progenitors. Nat Commun.

    2016 Nov 21;7:13396. doi: 10.1038/ncomms13396. PMID: 27869129; PMCID: PMC5121332.

  • Khattar E, Kumar P, Liu CY, AkéÒncéÒlar SC, Raju A, Lakshmanan M, Maury JJ, Qiang Y, Li S, Tan EY, Hui KM, Shi M, Loh YH, Tergaonkar V

    Telomerase reverse transcriptase promotes cancer cell proliferation by augmenting tRNA expression. J Clin Invest.

    2016 Oct 3;126(10):4045-4060. doi: 10.1172/JCI86042. Epub 2016 Sep 19. PMID: 27643433; PMCID: PMC5096818.

  • Cheow LF, Courtois ET, Tan Y, Viswanathan R, Xing Q, Tan RZ, Tan DS, Robson P, Loh YH, Quake SR, Burkholder WF

    Single-cell multimodal profiling reveals cellular epigenetic heterogeneity. Nat Methods.

    2016 Oct;13(10):833-6. doi: 10.1038/nmeth.3961. Epub 2016 Aug 15. PMID: 27525975.

  • Chen HY, Tan HK, Loh YH

    Derivation of Transgene-Free Induced Pluripotent Stem Cells from a Single Drop of Blood. Curr Protoc Stem Cell Biol.

    2016 Aug 17;38:4A.9.1-4A.9.10. doi: 10.1002/cpsc.12. PMID: 27532818.

  • Sivalingam J, Lam AT, Chen HY, Yang BX, Chen AK, Reuveny S, Loh YH, Oh SK

    Superior Red Blood Cell Generation from Human Pluripotent Stem Cells Through a Novel Microcarrier-Based Embryoid Body Platform. Tissue Eng Part C Methods.

    2016 Aug;22(8):765-80. doi: 10.1089/ten.TEC.2015.0579. Epub 2016 Aug 1. PMID: 27392822.

  • Zhang J, Ratanasirintrawoot S, Chandrasekaran S, Wu Z, Ficarro SB, Yu C, Ross CA, Cacchiarelli D, Xia Q, Seligson M, Shinoda G, Xie W, Cahan P, Wang L, Ng SC, Tintara S, Trapnell C, Onder T, Loh YH, Mikkelsen T, Sliz P, Teitell MA, Asara JM, Marto JA, Li H, Collins JJ, Daley GQ

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    Gene networks of fully connected triads with complete auto-activation enable multistability and stepwise stochastic transitions. PLoS One.

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    Euchromatin islands in large heterochromatin domains are enriched for CTCF binding and differentially DNA-methylated regions. BMC Genomics.

    2012 Oct 26;13:566. doi: 10.1186/1471-2164-13-566. PMID: 23102236; PMCID: PMC3507770.

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    2012 Jun;22(3):272-82. doi: 10.1016/j.gde.2012.03.001. Epub 2012 Mar 29. PMID: 22463982; PMCID: PMC4171054.

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    Excision of a viral reprogramming cassette by delivery of synthetic CremRNA. Curr Protoc Stem Cell Biol. Curr Protoc Stem Cell Biol.

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    Reproductive medicine gets a new tool. J Mol Cell Biol.

    2011 Dec;3(6):320-1. doi: 10.1093/jmcb/mjr027. Epub 2011 Nov 24. PMID: 22116889.

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    2011 Nov 27;29(12):1117-9. doi: 10.1038/nbt.2052.

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    Somatic coding mutations in human induced pluripotent stem cells. Nature.

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    Large intergenic non-coding RNA-RoR modulates reprogramming of human induced pluripotent stem cells. Nat Genet.

    2010 Dec;42(12):1113-7. doi: 10.1038/ng.710. Epub 2010 Nov 7.

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    2010 Jul 2;7(1):15-9. doi: 10.1016/j.stem.2010.06.004. PMID: 20621044; PMCID: PMC2913590.

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    Telomere elongation in induced pluripotent stem cells from dyskeratosis congenita patients. Nature.

    2010 Mar 11;464(7286):292-6. doi: 10.1038/nature08792. Epub 2010 Feb 17. PMID: 20164838; PMCID: PMC3058620.

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    2009 Nov 1;23(21):2507-20. doi: 10.1101/gad.1831909. PMID: 19884257; PMCID: PMC2779752.

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    2009 Nov;27(11):1033-7. doi: 10.1038/nbt.1580. Epub 2009 Oct 11. PMID: 19826408.

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LOH Yuin-Han Jonathan
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Email: yhloh@a-star.edu.sg

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